iProt-Sub is an integrated feature-based webserver in silico prediction of protease substrates and their cleavage sites for 38 different protease types, covering four major protease families: Aspartic (A), Cysteine (C), Metallo (M) and Serine (S).
Citation
Important Notice: We rely on good outcomes from the use of the bioinformatics tools that we have developed for funding and other important considerations. To continue this high-quality service and to enable the further development of cutting-edge tools that meet users' needs, we ask you to consider citing the publication on iProt-Sub if you get great outcomes from using our service: Song J, Wang Y, Li F, et al., 2018, iProt-Sub: a comprehensive package for accurately mapping and predicting protease-specific substrates and cleavage sites. Submitted for publication.
Table: The list of the proteases which can be analyzed via iProt-Sub
| Proteases name | Merops ID | Species | Family |
|---|---|---|---|
| Cathepsin D | A01.009 | Homo sapiens | Aspartic |
| Cathepsin D | A01.009 | Mus Musculus | |
| Cathepsin E | A01.010 | Mus Musculus | |
| Cathepsin L | C01.032 | Homo sapiens | Cysteine |
| Calpain-1 | C02.001 | Homo sapiens | |
| Calpain-2 | C02.002 | Homo sapiens | |
| Caspase-1 | C14.001 | Mus Musculus | |
| Caspase-3 | C14.003 | Homo sapiens | |
| Caspase-7 | C14.004 | Homo sapiens | |
| Caspase-6 | C14.005 | Homo sapiens | |
| Caspase-8 | C14.009 | Homo sapiens | |
| Matrix Metallopeptidase-1 | M10.001 | Homo sapiens | Metallo |
| Matrix Metallopeptidase-8 | M10.002 | Homo sapiens | |
| Matrix Metallopeptidase-2 | M10.003 | Homo sapiens | |
| Matrix Metallopeptidase-9 | M10.004 | Homo sapiens | |
| Matrix Metallopeptidase-3 | M10.005 | Homo sapiens | |
| Matrix Metallopeptidase-7 | M10.008 | Homo sapiens | |
| Matrix Metallopeptidase-12 | M10.009 | Homo sapiens | |
| Matrix Metallopeptidase-13 | M10.013 | Homo sapiens | |
| Membrane-type Matrix Metallopeptidase-12 | M10.014 | Homo sapiens | |
| ADAMTS4 Peptidase | M12.221 | Homo sapiens | |
| Neprilysin | M13.001 | Homo sapiens | |
| Insulysin | M16.002 | Homo sapiens | |
| Granzyme B | S01.010 | Homo sapiens | Serine |
| Granzyme B | S01.010 | Mus Musculus | |
| Kallikrein-related Peptidase 5 | S01.017 | Homo sapiens | |
| Elastase-2 | S01.131 | Homo sapiens | |
| Granzyme A | S01.135 | Homo sapiens | |
| Granzyme B | S01.136 | Homo sapiens | |
| Granzyme B | S01.136 | Mus Musculus | |
| Granzyme M | S01.139 | Homo sapiens | |
| Plasmin | S01.233 | Homo sapiens | |
| Kallikrein-related Peptidase 4 | S01.251 | Homo sapiens | |
| Furin | S08.071 | Homo sapiens | |
| PCSK2 Peptidase | S08.073 | Mus Musculus | |
| KPC2-type Peptidase | S08.109 | Caenorhabditis Elegans | |
| Signal Peptidase I | S26.001 | Escherichia Coli | |
| Signal Peptidase I | S26.001 | Salmonella Typhimurium |
